Relationships among tumor necrosis factor‐alpha levels, beta‐amyloid accumulation, and hippocampal atrophy in patients with late‐life major depressive disorder

This study highlights elevated TNF-α levels and reduced hippocampal volume in MCI MDD patients, indicating a potential association between peripheral inflammation and structural brain alterations in depression. Furthermore, our results suggest that certain cases of MDD may be affected by non-amyloid-mediated process, which impacts their TNF-α and hippocampal volume. These findings emphasize the importance of further investigating the complex interplay among inflammation, neurodegeneration, and cognitive function in MDD.

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Publication Details

Journal
Brain and Behavior
Published
2024-09-01
DOI
https://doi.org/10.1002/brb3.70016
Citations
9
Primary Topic
Tryptophan and brain disorders
Type
article
Field-Weighted Citation Impact
1.42

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article

Relationships among tumor necrosis factor‐alpha levels, beta‐amyloid accumulation, and hippocampal atrophy in patients with late‐life major depressive disorder

Ing‐Tsung Hsiao, Kun‐Ju Lin, Yiming Wu, Kuan‐Yi Wu et al.
9 citations
Brain and Behavior
Tryptophan and brain disorders
1.42
article

Relationships among tumor necrosis factor‐alpha levels, beta‐amyloid accumulation, and hippocampal atrophy in patients with late‐life major depressive disorder

Ing‐Tsung Hsiao, Kun‐Ju Lin, Yiming Wu, Kuan‐Yi Wu, Szu‐Kai Ho
article en
9 citations

Abstract

This study highlights elevated TNF-α levels and reduced hippocampal volume in MCI MDD patients, indicating a potential association between peripheral inflammation and structural brain alterations in depression. Furthermore, our results suggest that certain cases of MDD may be affected by non-amyloid-mediated process, which impacts their TNF-α and hippocampal volume. These findings emphasize the importance of further investigating the complex interplay among inflammation, neurodegeneration, and cognitive function in MDD.

Brain and BehaviorVol. 14(9)
Chang Gung University (TW), Chang Gung Memorial Hospital (TW), Taoyuan Chang Gung Memorial Hospital (TW)
Clinical Trial Center, China Medical University Hospital, Ministry of Health and Welfare, Chang Gung Medical Foundation, Ministry of Science and Technology, Taiwan, Chang Gung Memorial Hospital, Linkou, Avid Radiopharmaceuticals
Openalex Percentile: Top 20%
Tryptophan and brain disorders
1.42
DOIOpen Access PDFOpenAlex
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Relationships among tumor necrosis factor‐alpha levels, beta‐amyloid accumulation, and hippocampal atrophy in patients with late‐life major depressive disorder — Ing‐Tsung Hsiao, Kun‐Ju Lin, et al. · Brain and Behavior (2024) | TGRS Research Map | TGRS