Human umbilical cord mesenchymal stem cells-derived extracellular vesicles ameliorate kidney ischemia-reperfusion injury by suppression of senescent tubular epithelial cells: experimental study
The combination of HUMSC-EVs and senolytics alleviated acute kidney injury and chronic interstitial fibrosis by dynamic regulation of cell senescence and apoptosis, which provides a therapeutic potential strategy for organ preservation and tissue repair in kidney transplantation.
Authors
- Tao Lin (ORCID: https://orcid.org/0000-0001-8584-7101)
- Jun Zeng (ORCID: https://orcid.org/0000-0002-8185-7940)
- Xin Wei (ORCID: https://orcid.org/0000-0001-8764-3428)
- Mengli Zhu
- Turun Song
- Hui Li (ORCID: https://orcid.org/0000-0002-6171-4934)
- Ming Ma (ORCID: https://orcid.org/0000-0002-4572-3267)
- Hao Yang (ORCID: https://orcid.org/0009-0007-7437-1815)
Institutions
- Sichuan University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1097/js9.0000000000002074
- Citations
- 5
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.17