Case of Autosomal-Dominant Alzheimer Disease With Ribbon-Like Cortical Calcifications

A 69-year-old man presented with recurrent headaches for 20 years, walking instability for 8 years, and memory loss and personality changes for 5 years.Those symptoms worsened 2 years Figure Cranial CT and MRI Findings of the Patient Carrying p.K687Q Pathogenic Variant in APP Cranial CT revealed "ribbon-like" (yellow arrowhead) cortical calcifications in the bilateral occipital cortex (A-C), which presented as hypointensities in the susceptibility-weighed imaging (D-F).Cranial MRI also showed diffuse symmetrical white matter hyperintensities in fluid attenuated inversion recovery (FLAIR) imaging, resembling the presentations of cerebral small vessel disease (G-I).