Neuromuscular impairment at different stages of human sarcopenia
Alterations in MU properties, axonal damage, an altered innervation profile and NMJ instability are prominent features of the ageing of the neuromuscular system. These neuromuscular alterations are accompanied by muscle wasting and weakness; however, they appear to precede clinically diagnosed sarcopenia, as they are already detectable in older NS individuals.
Authors
- Sandra Zampieri (ORCID: https://orcid.org/0000-0001-6970-0011)
- Martino V. Franchi (ORCID: https://orcid.org/0000-0003-3165-4536)
- Giacomo Valli (ORCID: https://orcid.org/0000-0002-5221-580X)
- Daniel W. Stashuk (ORCID: https://orcid.org/0000-0002-8072-8135)
- Elena Monti (ORCID: https://orcid.org/0000-0002-3767-0855)
- Maira Rossi (ORCID: https://orcid.org/0000-0001-8199-4999)
- Evgeniia Motanova (ORCID: https://orcid.org/0000-0002-2200-9191)
- Tatiana Moro (ORCID: https://orcid.org/0000-0002-1404-1511)
- Giuseppe De Vito (ORCID: https://orcid.org/0000-0002-6855-9180)
- Marco Narici (ORCID: https://orcid.org/0000-0003-0167-1845)
- Antonio Paoli (ORCID: https://orcid.org/0000-0003-0474-4229)
- Roberto Bottinelli (ORCID: https://orcid.org/0000-0002-4960-7490)
- Maria Antonietta Pellegrino (ORCID: https://orcid.org/0000-0002-1653-1266)
- Jamie S. McPhee (ORCID: https://orcid.org/0000-0002-3659-0773)
- Matteo Paganini (ORCID: https://orcid.org/0000-0002-7556-6928)
- Giuseppe Sirago (ORCID: https://orcid.org/0000-0001-7005-8708)
- Fabio Sarto (ORCID: https://orcid.org/0000-0001-8572-5147)
- Helen M. Blau (ORCID: https://orcid.org/0000-0001-6503-5480)
Institutions
- Manchester Metropolitan University (GB)
- University of Padua (IT)
- University of Waterloo (CA)
- University of Pavia (IT)
- Stanford University (US)
- University of Lausanne (CH)
- Baxter (United States) (US)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1002/jcsm.13531
- Citations
- 40
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 13.06
Funders
- Li Ka Shing Foundation
- Donald E. and Delia B. Baxter Foundation