Integrin Beta-Like 1 is Regulated by DNA Methylation and Increased in Heart Failure Patients
ITGBL1 is a gene that is mainly expressed in fibroblasts, plays an important role in cardiac fibroblast migration, and whose expression is significantly increased in the failing heart. The mechanism by which increased ITGBL1 occurs is through DNA hypomethylation.
Authors
- Carlos Galán‐Arriola (ORCID: https://orcid.org/0000-0001-7403-8974)
- Mark Ledwidge (ORCID: https://orcid.org/0000-0001-7391-2949)
- Kenneth McDonald (ORCID: https://orcid.org/0000-0001-8011-3301)
- David Simpson (ORCID: https://orcid.org/0000-0003-0157-1211)
- Adam Russell‐Hallinan (ORCID: https://orcid.org/0000-0002-4752-1976)
- Borja Ibáñez (ORCID: https://orcid.org/0000-0002-5036-254X)
- David Grieve (ORCID: https://orcid.org/0000-0002-3655-7754)
- John Andrew Baugh (ORCID: https://orcid.org/0000-0002-5357-5575)
- Kevin J. Edgar (ORCID: https://orcid.org/0000-0002-9459-9477)
- Christopher J.E. Watson (ORCID: https://orcid.org/0000-0002-0590-4901)
- Patrick Collier (ORCID: https://orcid.org/0000-0003-3941-9653)
- Eduardo Oliver (ORCID: https://orcid.org/0000-0001-9340-882X)
- Oisín Cappa (ORCID: https://orcid.org/0000-0002-3015-3345)
- Nadezhda Glezeva (ORCID: https://orcid.org/0000-0003-2117-1186)
- Lauren Kerrigan (ORCID: https://orcid.org/0000-0001-9185-4666)
- Sudipto Das (ORCID: https://orcid.org/0009-0000-8325-0088)
Institutions
- University College Dublin (IE)
- Queen's University Belfast (GB)
- Cleveland Clinic (US)
- Royal College of Surgeons in Ireland (IE)
- Spanish National Centre for Cardiovascular Research (ES)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1002/ehf2.15050
- Citations
- 4
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- British Heart Foundation
- Heart Research UK
- Queen's University Belfast
- Ulster University
- Queen's University