Ameliorating effect of chotosan and its active component, Uncaria hook, on lipopolysaccharide-induced anxiety-like behavior in mice
These findings indicate that chotosan exerts anxiolytic-like effects in the context of inflammation-induced anxiety, potentially mediated by the inhibition of 5-HT<sub>2A</sub> receptor hyperfunction in LPS-treated mice. Consequently, we postulate that chotosan may be effective in managing inflammation-induced anxiety-like behaviors.
Authors
- Soichiro Ushio (ORCID: https://orcid.org/0000-0003-4365-7857)
- Yasumasa Okawa
- Yoshito Zamami (ORCID: https://orcid.org/0000-0002-7879-423X)
- Yasuhisa Izushi (ORCID: https://orcid.org/0000-0001-8210-4687)
- Yoshihisa Kitamura (ORCID: https://orcid.org/0000-0002-3652-3722)
- Toshiaki Sendo
Institutions
- Shujitsu University (JP)
- Okayama University (JP)
- Fukuoka University (JP)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-04
- DOI
- https://doi.org/10.3389/fphar.2024.1471602
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.16