Exploring expression levels of the cGAS-STING pathway genes in peripheral blood mononuclear cells of spinal tuberculosis patients
The expression level of TBK1 and IRF3 in PBMCs, and IFN-β in the serum of patients with spinal TB is positively correlated with disease activity. TBK1 has higher specificity and IFN-β in serum has higher sensitivity when used to differentiate between patients with active and stable lesions.
Authors
- Xiyong Dai (ORCID: https://orcid.org/0000-0002-3567-0368)
- Feng Xu (ORCID: https://orcid.org/0000-0002-8102-3903)
- Jing Feng (ORCID: https://orcid.org/0000-0003-2855-6994)
- Junwen Wang (ORCID: https://orcid.org/0000-0002-4432-4707)
- Xianglin Peng
- Ping Xia (ORCID: https://orcid.org/0000-0002-5675-3293)
- Feifei Pu (ORCID: https://orcid.org/0000-0002-9174-8780)
- Fangzheng Zhou
Institutions
- Wuhan Puai Hospital (CN)
- Wuhan Pulmonary Hospital (CN)
- Wuhan No.1 Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2024-09-04
- DOI
- https://doi.org/10.1186/s12879-024-09815-x
- Citations
- 2
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- Health and Family Planning Commission of Wuhan Municipality