Case report: Concurrent MOG antibody-associated disease and latent infections in two patients
The coexistence of MOGAD diagnoses and latent syphilis, alongside the identification of antibody reactivity to MOG and <i>T. pallidum</i>, underscores the potential pathomechanistic link between syphilis infection and subsequent autoimmune neuroinflammation. Cross-reactivity between MOG and <i>T. pallidum</i> antibodies remains to be validated on a molecular level, and further characterization of infectious triggers associated with MOGAD is needed.
Authors
- Ana Beatriz Ayroza Galvão Ribeiro Gomes (ORCID: https://orcid.org/0000-0003-1657-6891)
- Laila Kulsvehagen (ORCID: https://orcid.org/0000-0001-5236-8323)
- Tradite Neziraj (ORCID: https://orcid.org/0000-0001-8428-604X)
- Jens Kühle (ORCID: https://orcid.org/0000-0002-6963-8892)
- Julia Flammer (ORCID: https://orcid.org/0000-0002-0817-5484)
- Karoline Leuzinger (ORCID: https://orcid.org/0000-0002-5654-9356)
- Patrick Lipps (ORCID: https://orcid.org/0009-0002-5910-7622)
- Tobias J Derfuss (ORCID: https://orcid.org/0000-0001-8656-4250)
- Athina Papadopoulou (ORCID: https://orcid.org/0000-0002-0367-1008)
- Anne‐Katrin Pröbstel (ORCID: https://orcid.org/0000-0002-7748-1872)
- Tim Woelfle (ORCID: https://orcid.org/0000-0001-6279-4158)
Institutions
- University of Basel (CH)
- University Hospital of Basel (CH)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-04
- DOI
- https://doi.org/10.3389/fimmu.2024.1455355
- Citations
- 4
- Primary Topic
- Otitis Media and Relapsing Polychondritis
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- National Science Foundation
- European Committee for Treatment and Research in Multiple Sclerosis
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Fondation Pierre Mercier
- Fondation Pierre Mercier pour la Science
- Staatssekretariat für Bildung, Forschung und Innovation