Olfr2-positive macrophages originate from monocytes proliferate <i>in situ</i> and present a pro-inflammatory foamy-like phenotype
In summary, we conclude that Olfr2+ macrophages in the aorta originate from monocytes and can accumulate at the early stages of disease progression. These cells can undergo differentiation into MacAir and Trem2Gpnmb foamy macrophages, exhibiting proliferative and pro-inflammatory potentials. This dynamic behaviour positions them as key influencers in shaping the myeloid landscape within the atherosclerotic plaque.
Authors
- Marco Orecchioni (ORCID: https://orcid.org/0000-0002-3602-8510)
- Klaus Ley (ORCID: https://orcid.org/0000-0001-9339-3672)
- Erpei Wang
- Felix Sebastian Nettersheim (ORCID: https://orcid.org/0000-0002-4090-3357)
- Sujit Silas Armstrong Suthahar (ORCID: https://orcid.org/0000-0002-2538-4691)
- Catherine C. Hedrick (ORCID: https://orcid.org/0000-0003-2045-4117)
- Payel Roy (ORCID: https://orcid.org/0000-0003-2511-068X)
- Monica Billitti
- Ahmad Alimadadi
- Natalya Resto-Trujillo
Institutions
- La Jolla Institute for Immunology (US)
- Augusta University (US)
- Augusta University Health (US)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1093/cvr/cvae153
- Citations
- 15
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.61
Funders
- American Heart Association
- Augusta University
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- National Heart, Lung, and Blood Institute