Comparison of Jinzhen oral liquid and ambroxol hydrochloride and clenbuterol hydrochloride oral solution in the treatment of acute bronchitis in children: A multicenter, non-inferiority, prospective, randomized controlled trial
The comparison between traditional Chinese medicine Jinzhen oral liquid (JZOL) and Western medicine in treating children with acute bronchitis (AB) showed encouraging outcomes. This trial evaluated the efficacy and safety of the JZOL for improving cough and expectoration in children with AB. 480 children were randomly assigned to take JZOL or ambroxol hydrochloride and clenbuterol hydrochloride oral solution for 7 days. The primary outcome was time-to-cough resolution. The median time-to-cough resolution in both groups was 5.0 days and the antitussive onset median time was only 1 day. This randomized controlled trial showed that JZOL was not inferior to cough suppressant and phlegm resolving western medicine in treating cough and sputum and could comprehensively treat respiratory and systemic discomfort symptoms. Combined with clinical trials, the mechanism of JZOL against AB was uncovered by network target analysis, it was found that the pathways in TRP channels like IL-1<i>β</i>/IL1R/TRPV1/TRPA1, NGF/TrkA/TRPV1/TRPA1, and PGE2/EP/PKA/TRPV1/TRPA1 might play important roles. Animal experiments further confirmed that inflammation and the immune regulatory effect of JZOL in the treatment of AB were of vital importance and TRP channels were the key mechanism of action.
Authors
- Qinhua Fan
- Yunying Xiao
- Qiangquan Rong
- Changshan Liu (ORCID: https://orcid.org/0000-0002-1828-8204)
- Yan‐Ming Xie (ORCID: https://orcid.org/0000-0001-5359-4242)
- Wenquan Su
- Xueqin Xi
- Xiaoli Huang (ORCID: https://orcid.org/0000-0002-2833-3523)
- Yufeng Liu (ORCID: https://orcid.org/0000-0002-2355-4706)
- Wei Pan
- Qianye Zhao
- Xinjiang An
- Ying Ding (ORCID: https://orcid.org/0000-0003-1352-1000)
- Zeling Zhang (ORCID: https://orcid.org/0000-0002-4624-3142)
- Shao Li (ORCID: https://orcid.org/0000-0002-8709-9167)
- Chongming Wu (ORCID: https://orcid.org/0000-0003-2898-370X)
- Changchang Xu (ORCID: https://orcid.org/0000-0002-8671-202X)
- Shengxian Wu
- Xueke Li (ORCID: https://orcid.org/0000-0003-3937-1274)
- Juan Wang (ORCID: https://orcid.org/0000-0003-1636-4450)
- Jing Chen (ORCID: https://orcid.org/0000-0002-0024-4561)
- Haitao Zhang (ORCID: https://orcid.org/0000-0002-9616-3079)
- Qin Shen (ORCID: https://orcid.org/0000-0001-6561-8467)
- Yuling Wen (ORCID: https://orcid.org/0009-0008-3211-4295)
- Yu Rong (ORCID: https://orcid.org/0000-0003-3365-5786)
- Boyang Wang (ORCID: https://orcid.org/0000-0002-5514-7339)
- Jianming Xu (ORCID: https://orcid.org/0000-0003-4467-6021)
- Junhong Wang (ORCID: https://orcid.org/0000-0003-2314-1810)
- Yiqun Teng
- Yawei Du (ORCID: https://orcid.org/0000-0001-7753-3946)
- Xia Yu (ORCID: https://orcid.org/0000-0001-5078-7962)
- Zizhuo Wang (ORCID: https://orcid.org/0000-0002-9659-0644)
- Hongfen Lv
- Lie Zhuo
- Nian Yang
- Nan Li
Institutions
- Qiqihar University (CN)
- Tianjin University of Traditional Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Liaoning University of Traditional Chinese Medicine (CN)
- Liuzhou Maternal and Child Health Hospital (CN)
- Kanion Pharmaceutical (China) (CN)
- Lianyungang Maternal and Children’s Hospital (CN)
- Linyi People's Hospital (CN)
- Fourth Affiliated Hospital of China Medical University (CN)
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- Taiyuan Maternity and Child Care Hospital (CN)
- Nanjing Drum Tower Hospital (CN)
- Gaochun People's Hospital (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- Wuxi No.2 People's Hospital (CN)
- Lishui City People's Hospital (CN)
- The First People’s Hospital of Lianyungang (CN)
- Second Hospital of Tianjin Medical University (CN)
- Suzhou Traditional Chinese Medicine Hospital (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (CN)
- Xuzhou Children Hospital (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
- First Hospital of Jiaxing (CN)
- First Affiliated Hospital of Henan University of Traditional Chinese Medicine (CN)
- Qidong Liver Cancer Prevention Research (CN)
- Wuxi Taihu Hospital (CN)
- Shandong Maternal and Child Health Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Qiqihar Institute of Engineering (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
- Tianjin Medical University (CN)
- Nanjing Medical University (CN)
- Qiqihar Medical University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Acta Pharmaceutica Sinica B
- Published
- 2024-09-04
- DOI
- https://doi.org/10.1016/j.apsb.2024.09.001
- Citations
- 8
- Primary Topic
- Respiratory and Cough-Related Research
- Type
- article
- Field-Weighted Citation Impact
- 3.35
Funders
- Tsinghua University
- Beijing University of Chinese Medicine
- National Key Research and Development Program of China