Familial Acute Promyelocytic Leukemia: A Case Report and Review of the Literature
Acute promyelocytic leukemia (APL) is characterized by a reciprocal translocation t (15;17) (q24;q21), which leads to the fusion of PML and RARα genes known as <i>PML-RARα</i> fusion. A few cases of potentially hereditary leukemia-related genes in APL have been reported, but no instances of familial aggregation of APL have been documented. Here, we describe a family in whom two members successively affected by APL。The potential familial association observed in these two cases of APL highlights the need for further investigation and more definitive genetic lineage tracing in order to understand the genetic basis of this disease.
Authors
- Yunju Ma (ORCID: https://orcid.org/0000-0003-1741-6849)
- Xiaowen Tang (ORCID: https://orcid.org/0000-0003-1766-7891)
- Xuanqi Cao
- Qingya Cui (ORCID: https://orcid.org/0000-0002-5067-5650)
- Lian Bai (ORCID: https://orcid.org/0009-0001-6097-6828)
- Mingqi Yang
- Depei Wu (ORCID: https://orcid.org/0009-0003-3176-9963)
Institutions
- Soochow University (CN)
- People's Hospital of Cangzhou (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- OncoTargets and Therapy
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/ott.s482781
- Citations
- 1
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Bethune Charitable Foundation
- National Natural Science Foundation of China
- Soochow University
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- China International Medical Foundation