The antifibrotic potential of IMT504: modulation of GLAST + Wnt1 + bone marrow stromal progenitors and hepatic microenvironment
In summary, our findings identify IMT504 as a promising candidate molecule with potent antifibrotic properties, operating through both direct and indirect mechanisms, including the activation of GLAST + Wnt1 + BMSPs.
Authors
- Julia Rubione (ORCID: https://orcid.org/0000-0002-7119-8216)
- Jorge B. Aquino (ORCID: https://orcid.org/0000-0002-3818-5181)
- Esteban Fiore (ORCID: https://orcid.org/0000-0003-1059-1695)
- Maximiliano Borda (ORCID: https://orcid.org/0000-0001-9486-1028)
- María José Cantero
- Mariana Garcı́a
- Alejandro D. Montaner (ORCID: https://orcid.org/0000-0003-3987-3055)
- Guillermo Mazzolini (ORCID: https://orcid.org/0000-0002-1450-8441)
- Juan Miguel Bayo Fina
- Romina Sierra (ORCID: https://orcid.org/0000-0003-2148-7922)
- Gianlucca Giardelli
- Matías Martino Garcet
- María Luz Rebottaro
- Máximo Schiavone
- Sofía Gómez Bustillo
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Austral University (AR)
- Hospital César Milstein (AR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-09-04
- DOI
- https://doi.org/10.1186/s13287-024-03896-w
- Citations
- 2
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Agencia Nacional de Promoción Científica y Tecnológica
- Fondo para la Investigación Científica y Tecnológica