MG-132 activates sodium palmitate-induced autophagy in human vascular smooth muscle cells and inhibits senescence via the PI3K/AKT/mTOR axis
MG-132 activates autophagy by inhibiting the PI3K/AKT/mTOR pathway, thereby inhibiting palmitate-induced proliferation, migration, and oxidative stress in vascular smooth muscle cells and suppressing their senescence.
Authors
- Dong Cheng (ORCID: https://orcid.org/0000-0002-2891-8759)
- Shishun Xie (ORCID: https://orcid.org/0009-0004-5662-5795)
- Wenqing Zhang (ORCID: https://orcid.org/0000-0002-3239-5241)
- Hongyuan Cheng
- Xiangjun Li (ORCID: https://orcid.org/0000-0003-4901-6065)
- Zixu Huyan
- Bing Du
- Zhiyun Shu (ORCID: https://orcid.org/0009-0005-0285-2818)
- Jiajia Wang (ORCID: https://orcid.org/0000-0003-2659-2502)
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2024-09-04
- DOI
- https://doi.org/10.1186/s12944-024-02268-w
- Citations
- 12
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 4.64
Funders
- Natural Science Foundation of Jilin Province
- People's Government of Jilin Province