Ischemic-Preconditioning Induced Serum Exosomal miR-133a-3p Improved Post-Myocardial Infarction Repair via Targeting LTBP1 and PPP2CA
IPC-exo inhibit excessive replacement fibrosis and improve cardiac function post-MI by transferring miR-133a-3p, the mechanism is associated with directly targeting LTBP1 and PPP2CA, and indirectly regulating TGF-β pathway in rats. Our finding provides potential therapeutic effect of IPC-induced exosomal miR-133a-3p for cardiac repair.
Authors
- Haijuan Zhu (ORCID: https://orcid.org/0000-0002-0407-3771)
- Shufang He (ORCID: https://orcid.org/0000-0001-9896-5705)
- Na Yang (ORCID: https://orcid.org/0000-0002-2943-9039)
- Jun‐Ma Yu (ORCID: https://orcid.org/0000-0003-4053-5942)
- Yong-Bo Hou
- Tian-Hao Cui
Institutions
- Wannan Medical College (CN)
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Third People's Hospital of Hefei (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/ijn.s463477
- Citations
- 6
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.40