Aberrant brain structural–functional connectivity coupling associated with cognitive dysfunction in different cerebral small vessel disease burdens
Our findings demonstrated that decreased whole-brain and module-dependent SC-FC coupling associated with reduced functional efficiency might underlie more severe burden and worse cognitive decline in CSVD. SC-FC coupling might serve as a more sensitive neuroimaging biomarker of CSVD burden and provided new insights into the pathophysiologic mechanisms of clinical development of CSVD.
Authors
- Chaofan Sui (ORCID: https://orcid.org/0000-0002-1049-3772)
- Mengmeng Feng (ORCID: https://orcid.org/0000-0001-5349-2780)
- Lingfei Guo (ORCID: https://orcid.org/0000-0002-4885-625X)
- Hongwei Wen (ORCID: https://orcid.org/0000-0003-1717-7235)
- Yajie Fu (ORCID: https://orcid.org/0000-0002-1195-5764)
- Haotian Xin (ORCID: https://orcid.org/0000-0001-8781-1815)
- Xinyue Zhang (ORCID: https://orcid.org/0000-0003-1643-608X)
- Yian Gao (ORCID: https://orcid.org/0000-0002-3444-3382)
- Yuanyuan Wang (ORCID: https://orcid.org/0000-0002-0641-8411)
- Changhu Liang (ORCID: https://orcid.org/0000-0003-3796-2978)
- Na Wang (ORCID: https://orcid.org/0000-0001-6191-4760)
- Nan Zhang (ORCID: https://orcid.org/0000-0002-6202-9349)
Institutions
- Binzhou Medical University (CN)
- Southwest University (CN)
- Shandong University of Aeronautics (CN)
- Capital Medical University (CN)
- Shandong Provincial Hospital (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1111/cns.70005
- Citations
- 9
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.08
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Fundamental Research Funds for the Central Universities