Prognostic significance of immune-cell distribution and tumoral spread through air spaces – Multiplex spatial immunophenotyping analysis–
Immune-cell distribution, particularly CD4, CD8, and FoxP3, is a crucial prognostic factor in lung cancer. STAS and specific immune cell distribution patterns can be used to further stratify patient prognosis. Understanding these interactions may provide insights into potential therapeutic targets for personalized lung cancer treatment.
Authors
- Shunichiro Matsuoka (ORCID: https://orcid.org/0000-0001-9351-5000)
- Kimihiro Shimizu (ORCID: https://orcid.org/0000-0003-4076-5174)
- Mai Iwaya (ORCID: https://orcid.org/0000-0003-2135-2219)
- Hirotaka Kumeda
- Takashi Eguchi (ORCID: https://orcid.org/0000-0001-9460-0696)
- Daisuke Hara (ORCID: https://orcid.org/0000-0002-8029-5974)
- Kazutoshi Hamanaka (ORCID: https://orcid.org/0000-0002-4640-5690)
- Shuji Mishima (ORCID: https://orcid.org/0000-0002-5807-3558)
- Takeshi Uehara (ORCID: https://orcid.org/0000-0002-7694-9015)
- Kentaro Miura (ORCID: https://orcid.org/0000-0001-6736-4712)
- Maho Seshimoto
Institutions
- Shinshu University (JP)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e37412
- Citations
- 2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Japan Society for the Promotion of Science