A Complete Response to Combined Immunotherapy in a Patient with an ATM plus SF3B1 Mutation and a Moderate Tumor Mutational Burden with a High-Grade Treatment-Emergent Neuroendocrine Prostate Cancer: Case Report and Review of the Literature
This case highlights the genetic profile of tumor with a rare combination of ATM and SF3B1 mutations that could be further explored as biomarkers for IO therapy in T-NEPC and other tumor types.
Authors
- Daniel Herchenhorn (ORCID: https://orcid.org/0000-0001-5166-848X)
- Helena Ferreira Bruzzi Porto (ORCID: https://orcid.org/0000-0002-2737-7743)
- Hannah Barboza Vianna Bekierman (ORCID: https://orcid.org/0000-0003-0363-1329)
- Evandro Lucena (ORCID: https://orcid.org/0000-0001-8195-0136)
- Felipe Andreiuolo (ORCID: https://orcid.org/0000-0002-2568-6155)
- Sérgio Altino de Almeida (ORCID: https://orcid.org/0000-0001-5667-5582)
- Sandip Pravin Patel (ORCID: https://orcid.org/0000-0002-8387-4840)
- Gabriela Carreiro Kubitschek Lopes (ORCID: https://orcid.org/0000-0002-3984-2040)
- Vinicius Freire
Institutions
- D’Or Institute for Research and Education (BR)
- Hospital Oftalmologico de Brasília (BR)
- Estácio (Brazil) (BR)
- University of California San Diego Medical Center (US)
- Instituto Nacional de Câncer - INCA (BR)
Publication Details
- Journal
- Case Reports in Oncology
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1159/000540573
- Citations
- 2
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.84