Trimetazidine Alleviates Bleomycin-Induced Pulmonary Fibrosis by Targeting the Long Noncoding RNA CBR3-AS1-Mediated miRNA-29 and Resistin-Like Molecule alpha 1: Deciphering a Novel Trifecta Role of LncRNA CBR3-AS1/miRNA-29/FIZZ1 Axis in Lung Fibrosis
Taken together, our study showed for the first time the interplay between epigenetic lncRNAs CBR3-AS1 and miRNA-29 in lung fibrosis and demonstrated that FIZZ1 could be a downregulatory gene for lncRNA CBR3-AS1 and miRNA-29. Our key findings demonstrate that TMZ significantly reduces the expression of fibrotic, oxidative stress, immunomodulatory, and inflammatory markers, along with epigenetic regulators associated with lung fibrosis. This validates its potential as an effective antifibrotic agent by targeting the CBR3-AS1/miRNA-29/FIZZ1 axis.
Authors
- Ghazi A. Bamagous (ORCID: https://orcid.org/0000-0002-9667-6974)
- Essa M. Saied (ORCID: https://orcid.org/0000-0002-7342-6200)
- Doaa I. Mohamed
- Hebatallah H. Abo Nahas (ORCID: https://orcid.org/0009-0004-6754-5045)
- Mariusz Jaremko (ORCID: https://orcid.org/0000-0002-0787-702X)
- Abdulmalik Saleh Alfawaz Altamimi (ORCID: https://orcid.org/0009-0002-8523-9039)
- Abdullah R. Alzahrani (ORCID: https://orcid.org/0000-0001-7782-0574)
- Dalia Alaa El-Din Aly El-Waseef (ORCID: https://orcid.org/0000-0001-8199-2512)
- Nasser A. Elhawary (ORCID: https://orcid.org/0000-0002-9137-351X)
- Alaa Hisham Falemban (ORCID: https://orcid.org/0000-0002-1335-1788)
- Soha M. Y. Mohamed
- Yasmine Gamal Sabry
- Ibrahim H Youssef
- Ibrahim Abdel Aziz Ibrahim
Institutions
- Ain Shams University (EG)
- Suez Canal University (EG)
- Prince Sattam Bin Abdulaziz University (SA)
- Al-Azhar University (EG)
- Umm al-Qura University (SA)
- Humboldt-Universität zu Berlin (DE)
- King Abdullah University of Science and Technology (SA)
- Port Said University (EG)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/dddt.s463626
- Citations
- 9
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.57