Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model
Low body weight in leptin overexpressing pigs adversely affects the reproductive performance, causing delayed puberty, irregular estrous cycles, and reduced breeding efficiency. This is linked to metabolic imbalances, an increased immune response, and altered ovarian functions. This study provides a theoretical basis for the complex mechanisms underlying leptin, and infertility by employing leptin-overexpressing female pigs.
Authors
- Kaixiang Xu (ORCID: https://orcid.org/0000-0001-6665-3360)
- Yubo Qing (ORCID: https://orcid.org/0000-0001-6183-6627)
- Jianxiong Guo (ORCID: https://orcid.org/0000-0002-0994-3297)
- Di Zou (ORCID: https://orcid.org/0000-0001-8435-9739)
- Ru‐Song Zhao (ORCID: https://orcid.org/0000-0002-6689-6474)
- Hong‐Jiang Wei (ORCID: https://orcid.org/0000-0002-5663-1093)
- Deling Jiao (ORCID: https://orcid.org/0000-0003-3894-7665)
- Chang Yang (ORCID: https://orcid.org/0000-0001-6678-3659)
- Taiyun Wei
- Muhammad Ameen Jamal
- Hong‐Ye Zhao (ORCID: https://orcid.org/0000-0002-5900-3033)
- Honghui Li (ORCID: https://orcid.org/0000-0001-6113-6831)
- Heng Zhao (ORCID: https://orcid.org/0000-0002-9320-5894)
- Xia Wang (ORCID: https://orcid.org/0009-0009-8470-0533)
- Wen Cheng
- Baoyu Jia
- Yixiao Cheng
- Shaoxia Pu
Institutions
- Shandong University (CN)
- Kunming Institute of Zoology (CN)
- Yunnan Agricultural University (CN)
- Chinese Academy of Sciences (CN)
- Suzhou Municipal Hospital (CN)
- Shandong Women’s University (CN)
Publication Details
- Journal
- Biological Research
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1186/s40659-024-00545-7
- Citations
- 4
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- Yunnan Provincial Science and Technology Department
- Major Science and Technology Projects in Yunnan Province