To evaluate the association between T1DM in offspring with a positive parental history of diabetes

STRUCTURED ABSTRACT Objective: The aim of this study was to measure the association between parental history of diabetes and the odds of an offspring having T1DM. Study Design: SHINE (NCT03312478) was a national, multi-center, case-control study, with a ratio of 1:2 (case: control). Place and Duration: The study was conducted at specialized pediatric centers for 10 months. Patient and Methods: Three hundred and seventy-five (125 cases and 250 controls) participants were enrolled in this study. Individuals aged ≥ 2 years and ≤ 20 years with T1DM and who were on insulin for the last 1 year and positive for one or more islet cell autoantibodies were included in the study. Primary data was collected at the time of enrolment. Participants were then contacted telephonically after 15 days for follow-up. Results: 58% (n=218) of participants were males (mean age 10.66 [3.4] years; mean HbA1c 7.05 [2.78]). 11% (n=14) of the cases were reported to have a family history of diabetes (T2DM 10.4% [n=13]; T1DM 0.8% [n=1]). Regarding the parental history of diabetes, 8% (n=10) mothers reported having diabetes as compared to 3.2% (n=4) fathers. No statistically significant association (p= 0.83, OR= 0.92, 95% CI: 0.404 -2.077) was observed between parental history of diabetes and the odds of an offspring being T1DM. Conclusion: The results of the study suggest no association between parental diabetic history and odds of occurrence of T1DM in offspring in a Pakistani cohort.