P007 WEB shape modifications: angiography–histopathology correlations in rabbits

<h3>Introduction</h3> WEB Shape Modification (WSM) over time is frequent after aneurysm treatment. (published in JNIS ; ref 1) <h3>Aim of Study</h3> Explored relationship between histopathological changes and angiographic evolution over time in experimental aneurysms in rabbits treated with WEB. <h3>Methods</h3> Quantitative WSM was assessed using flat-panel CT (FPCT) during follow-up by calculating height and width ratio (HR, WR), defined as the ratio between either measurement at an index time point and the measurement immediately after WEB implantation. HR and WR were evaluated with angiographic and histopathological assessments of aneurysm healing. <h3>Results</h3> Altogether, at least 5% of HR and WR variations were observed in 37/40 (92,5%) and 28/40 (70%) WEB devices, respectively, at the time of final assessment. Histopathological analysis revealed a significant association between WR and aneurysm healing and fibrosis 1 month following aneurysm treatment (both p&lt;0.05). (Figure 1) <h3>Conclusion</h3> Using longitudinal FPCT assessment, we observed that WSM affects both the height and width of WEB device. No significant association was found between WSM and aneurysm occlusion status. Although presumably a multifactorial phenomenon, the histopathological analysis highlighted a significant association between width variations, aneurysm healing and fibrosis in the first month following aneurysm treatment. <h3>Reference</h3> Janot K, Boulouis G, Forestier G, <i>et al.</i> WEB shape modifications: angiography–histopathology correlations in rabbits. <i>J NeuroIntervent Surg</i>. 2023;jnis-2023-020193. <h3>Disclosure of Interest</h3> no.