P083 Aneurysm wall enhancement and radiomic features could help identifying the symptomatic aneurysm in patients with multiple intracranial aneurysms

<h3>Introduction</h3> Identifying the symptomatic aneurysm in patients with multiple intracranial aneurysms (MIAs) can be challenging. Aneurysm wall enhancement (AWE) is a potential tool for assessing intracranial aneurysms (IAs).¹ Radiomic features (RFs) offers detailed voxel-imaging analysis.² AWE and RFs can offer a novel approach in the assessment of symptomatic aneurysms in patients with MIAs. <h3>Aim of Study</h3> Analyze AWE and RFs of symptomatic aneurysms in patients with MIAs. <h3>Methods</h3> Patients with MIAs underwent high resolution 3T MRI. Manual segmentations of the aneurysm wall were created using 3D Slicer. RFs were extracted using an add-in. A previously described pipeline was employed to quantify the signal intensity (SI) of the aneurysm wall.³ The mean SI after gadolinium administration was computed and defined as three dimensional-circumferential AWE (3D-CAWE). Aneurysms with a 3D-CAWE higher than the mean SI of the corpus callosum post gadolinium were classified as positive. Student’s t test and logistic regression were conducted for the statistical analysis. <h3>Results</h3> Twenty patients with MIAs and a total of 47 saccular aneurysms were included. 7 aneurysms were symptomatic and 40 were asymptomatic. 130 RFs were extracted. 3D-CAWE was different between symptomatic and asymptomatic aneurysms (<i>p&lt; 0.05</i>). 3D-CAWE positive IAs were more likely to be symptomatic (OR= 23.75, <i>p=0.04</i>). Three RFs were different (<i>p&lt;0.05</i>) between symptomatic and asymptomatic IAs. <h3>Conclusion</h3> 3D-CAWE and radiomics analysis could help identify the symptomatic aneurysm in patients with MIAs.