P107 Treatment of symptomatic epilepsy in individuals with brain AVMs: a comparison of endovascular and surgical approaches. Experience of the national center of neurosurgery for 12 years

<h3>Introduction</h3> Arteriovenous malformations in the brain can lead to epilepsy. <h3>Aim of Study</h3> This study aimed to compare the outcomes of microsurgical and endovascular treatment for patients with epilepsy linked to AVM. <h3>Methods</h3> In this retrospective observational investigation, all patients with brain arteriovenous malformations (AVMs) treated at the National Center of Neurosurgery between 2008 and 2020 were to be reviewed. <h3>Results</h3> From 2008 to 2020, a cohort of 421 patients with arteriovenous malformations was observed, with 116 experiencing seizures and 27 undergoing microsurgical resection. Only fifteen percent had totally embolized AVM; the other patients only had partial embolization The average follow-up period was 98.07 ± 23.7 months. 40.7% presented with focal-onset seizures, and 59.3% with generalized-onset seizures. Among the patients who did not become seizure-free post-surgery, 4 were not on antiepileptic drugs beforehand but initiated treatment with carbamazepine after the operation. Two patients continued with valproic acid, while one switched from valproic acid to carbamazepine, and others increased carbamazepine dosage Post-operation, 15 out of 27 patients achieved seizure remission. The remainder included 3 in Engel Class IA, 3 in IB, 2 in IIA, 3 in IIIA, and 2 in IVB. Moreover, 6 patients were Rated ILAE Class 3, 3 were Rated ILAE Class 5, and 2 were Rated ILAE Class 1. <h3>Conclusion</h3> The analysis revealed that the frequency and duration of seizures preceding surgery were statistically significant factors affecting the postoperative use of AEDs. The study found that patients with arteriovenous malformations and epilepsy had varying outcomes after microsurgical resection <h3>Disclosure of Interest</h3> no.