Early Circulating Tumor DNA Shedding Kinetics for Prediction of Platinum Sensitivity in Patients With Small Cell Lung Cancer
A >2-fold decrease in ctDNA concentration was observed by C2D1 in all patients who were sensitive to platinum-based therapy and was associated with longer PFS and OS.
Authors
- Ritika Kundra (ORCID: https://orcid.org/0000-0001-6723-2859)
- Maximilian Diehn (ORCID: https://orcid.org/0000-0003-2032-0581)
- Angela BY Hui
- Michael David Offin (ORCID: https://orcid.org/0000-0002-7959-3018)
- Ash A. Alizadeh (ORCID: https://orcid.org/0000-0002-5153-5625)
- Emily S. Lebow (ORCID: https://orcid.org/0000-0002-6614-0212)
- Michelle S. Ginsberg (ORCID: https://orcid.org/0000-0003-0304-110X)
- Everett J. Moding (ORCID: https://orcid.org/0000-0001-7913-5351)
- Pedram Razavi (ORCID: https://orcid.org/0000-0003-4236-0576)
- Emily G. Hamilton (ORCID: https://orcid.org/0000-0001-7955-6244)
- Yonina R. Murciano‐Goroff (ORCID: https://orcid.org/0000-0001-9027-2891)
- Rene F. Bonilla
- Larry Norton (ORCID: https://orcid.org/0000-0003-3701-9250)
- Bob T. Li (ORCID: https://orcid.org/0000-0001-6661-8733)
- Charles M. Rudin (ORCID: https://orcid.org/0000-0001-5204-3465)
- Andreas Rimner (ORCID: https://orcid.org/0000-0002-1214-3856)
- Viola Allaj
- Alexander Edward Dela Cruz Drilon (ORCID: https://orcid.org/0000-0001-6806-9061)
- David R. Jones (ORCID: https://orcid.org/0000-0002-3318-0146)
- Jacob J. Chabon (ORCID: https://orcid.org/0000-0003-1820-9737)
- W. Victoria Lai (ORCID: https://orcid.org/0000-0003-2918-2728)
- José de Arimateia Batista Araújo-Filho (ORCID: https://orcid.org/0000-0002-8627-3661)
- James M. Isbell (ORCID: https://orcid.org/0000-0002-7305-876X)
- Jorge S. Reis-Filho
- Daniel Gomez
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- California Institute for Regenerative Medicine (US)
- Cornell University (US)
- Weill Cornell Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1200/po.24.00216
- Citations
- 8
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.98
Funders
- Conquer Cancer Foundation
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Tobacco-Related Disease Research Program
- American Society of Clinical Oncology
- Virginia and D.K. Ludwig Fund for Cancer Research
- Celgene
- Memorial Sloan-Kettering Cancer Center
- Varian Medical Systems
- Regeneron Pharmaceuticals
- Intuitive Surgical
- Jazz Pharmaceuticals
- Andrew Sabin Family Foundation
- Georgia Clinical and Translational Science Alliance
- Mirati Therapeutics
- Revolution Medicines
- Invitae
- National Institutes of Health
- Genentech
- School of Medicine, Stanford University
- Loxo Oncology
- National Cancer Institute
- Daiichi Sankyo Europe