Role of Cholesterol Metabolic Enzyme CYP46A1 and Its Metabolite 24S-Hydroxycholesterol in Ischemic Stroke
These results identify a new mechanism and signaling cascade that critically impacts stroke outcome: CYP46A1 → 24S-HC → NMDAR → ischemic brain injury. They offer proof of principle for further development of new strategies for stroke intervention by targeting CYP46A1 or its metabolite 24S-HC.
Authors
- Tiandong Leng (ORCID: https://orcid.org/0000-0003-2072-4340)
- Zhi‐Gang Xiong
- Tao Yang (ORCID: https://orcid.org/0000-0001-6178-1021)
- Roger P. Simon (ORCID: https://orcid.org/0000-0001-7287-6915)
- Huawei Sun (ORCID: https://orcid.org/0009-0003-8516-5313)
Institutions
- Morehouse School of Medicine (US)
Publication Details
- Journal
- Stroke
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1161/strokeaha.124.047803
- Citations
- 6
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 2.15