Mild and Catalytic Synthesis of Pyrroles from Vinyl Ethynylethylene Carbonates
A tandem remote propargylic amination/ring closure/aromatization reaction of vinyl ethynylethylene carbonates and amines has been developed, successfully constructing pyrrole derivatives. The reaction features mild conditions, high regioselectivity, high yields, and good functional group tolerance, making it an efficient method for pyrrole synthesis. Importantly, a variety of substrates containing natural product skeletons could also be compatibly and efficiently converted into pyrroles under the reaction conditions.
Authors
- Jianwei Sun (ORCID: https://orcid.org/0000-0002-2470-1077)
- Hai Huang (ORCID: https://orcid.org/0000-0002-9732-1454)
- Zhengyu Han (ORCID: https://orcid.org/0000-0001-8317-6439)
- Jixing Li (ORCID: https://orcid.org/0000-0001-7136-2234)
- Maoyan Liao
- Haihui Zhu
Institutions
- Hong Kong University of Science and Technology (HK)
- Changzhou University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1021/acs.joc.4c00853
- Citations
- 10
- Primary Topic
- Synthesis and Characterization of Pyrroles
- Type
- article
- Field-Weighted Citation Impact
- 2.50
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province
- Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology Department