Functional role of lncRNA MEG3 on pyroptosis through interacting with EZH2 and YTHDC1 in postoperative cognitive dysfunction
In conclusion, our study elucidates that MEG3 inhibits the NLRP3 inflammasome and hippocampal neuron pyroptosis through the recruitment of EZH2/YTHDC1. These findings shed light on the underlying mechanism of MEG3 in the regulation of POCD and suggest that MEG3 could serve as a potential therapeutic target for the treatment of POCD.
Authors
- Yan Li
- Zijian Ma (ORCID: https://orcid.org/0000-0002-3044-8442)
- Haifei Niu
- Haiqi Qi
Institutions
- Affiliated Hospital of Chengde Medical College (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1016/j.brainresbull.2024.111060
- Citations
- 5
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.43