The Use of Personalized Pharmabiotics as an Approach to the Rehabilitation of Post-COVID Patients

Successful application of defined pro- and/prebiotic preparations for the prevention and treatment of viral respiratory infections is confirmed by meta-analyses and numerous clinical trials. To date, the protocols for the rehabilitation of patients with post-COVID conditions, an integral part of which is the restoration of the balance of gut microbiota along with nutritional supportу, are widely developed and accepted. Purpose. To investigate the efficacy of individually prescribed pharmabiotics for targeted correction of the nasal and gut microbiota of post-COVID-19 patients in combination with aerosol inhalations. Methods. The post-COVID-19 patients were referred to recover using the rehabilitation facilities. In addition to the basic treatment complex, the patients were offered haloaerosol therapy with an additional prescription of individually selected pharmabiotics. Results. The use of individually prescribed pharmabiotics in combination with aerosol inhalation enabled therestoration of Lactobacillus spp. balance and reduction in the number of opportunistic microbiota in the gut. Thus, the personalized rehabilitation approach led to significantly improved local immune response in post-COVID-19 patients. Conclusions. The data obtained provide supportive evidence of the efficacy of aerosol inhalations and personalized pharmabiotics Lactobacillus rhamnosus S25 and L. plantarum A combined application in the directed modulation of the microbiome and targeted correction of local immunity in post-COVID patients. Restoring the balance of the patient’s' oral and gut microbiota should be an integral part of the post-COVID patient’s rehabilitation.