Molecular characterization of metastatic penile squamous cell carcinoma in developing countries and its impact on clinical outcomes: LACOG 2018 translational study
This study demonstrated that molecular alterations in mPSCC from developing countries are similar to those from developed countries. Predictive biomarkers for immunotherapy response such as TMB high or MSI were not identified. Specific gene mutations may identify patients with worse prognoses and open new avenues for therapeutic development.
Authors
- Antonio Augusto Lima Teixeira
- Gyl Eanes Barros Silva (ORCID: https://orcid.org/0000-0001-6625-6488)
- Rafaela Gomes de Jesus (ORCID: https://orcid.org/0000-0001-6912-2995)
- Pablo M. Barrios
- Philippe E. Spiess (ORCID: https://orcid.org/0000-0002-5723-1972)
- Antonio Machado Alencar
- Fernando Sabino Marques Monteiro (ORCID: https://orcid.org/0000-0002-6621-8251)
- Joaquim Bellmunt (ORCID: https://orcid.org/0000-0003-2328-3421)
- André P. Fay (ORCID: https://orcid.org/0000-0002-8588-7012)
- Karine Martins da Trindade (ORCID: https://orcid.org/0009-0006-4947-0304)
- Taiane Francieli Rebelatto (ORCID: https://orcid.org/0000-0001-7306-5428)
- Fernando Cotait Maluf (ORCID: https://orcid.org/0000-0002-4288-9018)
- Antonia A Gazzola
Institutions
- Harvard University (US)
- Hospital Israelita Albert Einstein (BR)
- Instituto Federal de Educação, Ciência e Tecnologia do Ceará (BR)
- Moffitt Cancer Center (US)
- Eastern Cooperative Oncology Group (US)
- Instituto de Ensino e Pesquisa Santa Casa (BR)
- Hospital Haroldo Juaçaba (BR)
- CTO Andrea Alesini (IT)
- Dana-Farber Cancer Institute (US)
- Hospital Universitário da Universidade Federal do Maranhão (BR)
- Hospital Sírio-Libanês (BR)
- Clinics Hospital of Ribeirão Preto (BR)
- Hospital Bandeirantes (BR)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- Insper (BR)
Publication Details
- Journal
- The Oncologist
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1093/oncolo/oyae220
- Citations
- 6
- Primary Topic
- Genital Health and Disease
- Type
- article
- Field-Weighted Citation Impact
- 3.44
Funders
- Foundation Medicine