The mesolimbic system and the loss of higher order network features in schizophrenia when learning without reward

Our analytical goals were linked to a recent circuit-based integrative model which argued that synergy between learning and reward circuits is lost in schizophrenia. The model's notable prediction was that such a loss would be observed even when patients learned without reward. Our results provide substantial support for these predictions where we observed a loss of network features between the brain's sub-circuits for a) learning (including the hippocampus and prefrontal cortex) and b) reward processing (specifically constituents of the mesolimbic system that included the ventral tegmental area and the nucleus accumbens. Our findings motivate a renewed appraisal of the relationship between reward and cognition in schizophrenia and we discuss their relevance for putative behavioral interventions.

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Publication Details

Journal
Frontiers in Psychiatry
Published
2024-09-03
DOI
https://doi.org/10.3389/fpsyt.2024.1337882
Citations
6
Primary Topic
Functional Brain Connectivity Studies
Type
article
Field-Weighted Citation Impact
2.06

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article

The mesolimbic system and the loss of higher order network features in schizophrenia when learning without reward

Vaibhav A. Diwadkar, Katharine N. Thakkar, Alfred J. Robison, Dalal Khatib et al.
6 citations
Frontiers in Psychiatry
Functional Brain Connectivity Studies
2.06
article

The mesolimbic system and the loss of higher order network features in schizophrenia when learning without reward

Vaibhav A. Diwadkar, Katharine N. Thakkar, Alfred J. Robison, Dalal Khatib, Alireza Amirsadri, Elizabeth L. Martin, John J. Kopchick, Usha Rajan, Caroline Zajac‐Benitez, Jeffrey A. Stanley, Patricia L. Thomas, Luay Haddad, Asadur Chowdury
article en
6 citations

Abstract

Our analytical goals were linked to a recent circuit-based integrative model which argued that synergy between learning and reward circuits is lost in schizophrenia. The model's notable prediction was that such a loss would be observed even when patients learned without reward. Our results provide substantial support for these predictions where we observed a loss of network features between the brain's sub-circuits for a) learning (including the hippocampus and prefrontal cortex) and b) reward processing (specifically constituents of the mesolimbic system that included the ventral tegmental area and the nucleus accumbens. Our findings motivate a renewed appraisal of the relationship between reward and cognition in schizophrenia and we discuss their relevance for putative behavioral interventions.

Frontiers in PsychiatryVol. 15
Wayne State University (US), University of Michigan (US), The University of Texas at Austin (US), Michigan State University (US)
Office of Extramural Research, National Institutes of Health
Openalex Percentile: Top 13%
Functional Brain Connectivity Studies
2.06
DOIOpen Access PDFOpenAlex
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The mesolimbic system and the loss of higher order network features in schizophrenia when learning without reward — Vaibhav A. Diwadkar, Katharine N. Thakkar, et al. · Frontiers in Psychiatry (2024) | TGRS Research Map | TGRS