Efficacy and safety of methotrexate plus hydroxychloroquine combination therapy vs. methotrexate monotherapy in the treatment of rheumatoid arthritis: A randomized controlled clinical trial
In our study, both the MTX + HCQ combination therapy and MTX monotherapy demonstrated improvements in symptoms, conditions and quality of life for patients with RA. Notably, the combination therapy could achieve better outcomes across all indices compared to MTX monotherapy, highlighting its potential as the optimal first-line treatment for RA. © 2024 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.
Authors
- Qiaoqiao Li (ORCID: https://orcid.org/0000-0001-9710-7135)
- Yan Jiang (ORCID: https://orcid.org/0000-0001-6153-1997)
- C. Hsu (ORCID: https://orcid.org/0000-0002-2060-8430)
- Jie Ma (ORCID: https://orcid.org/0000-0001-5346-8457)
- Jiasheng Ma (ORCID: https://orcid.org/0000-0003-1621-7151)
- Miaoyu Zeng
- Brian Shiian Chen (ORCID: https://orcid.org/0000-0001-5068-9457)
- Fengju Li (ORCID: https://orcid.org/0000-0003-0474-7358)
- Mei Na Fok
- Dandan Li (ORCID: https://orcid.org/0000-0002-9753-2331)
- Jiaze Zhou
Institutions
- Sun Yat-sen University (CN)
- Daqing Oilfield General Hospital (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
- Hospital Conde S. Januário (CN)
- Henan Medical University (CN)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- International Journal of Rheumatic Diseases
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1111/1756-185x.15319
- Citations
- 2
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.94