Deciphering colorectal cancer radioresistance and immune microrenvironment: unraveling the role of EIF5A through single-cell RNA sequencing and machine learning
EIF5A contributes to CRC radioresistance by promoting CSC traits via the Hedgehog pathway and modulating the TiME to an immune-suppressive state. Targeting EIF5A could enhance radiation sensitivity and improve immune responses, offering a potential therapeutic strategy to optimize radiotherapy outcomes in CRC patients.
Authors
- Xingte Chen
- Yaqi Zhong
- Lingdong Shao (ORCID: https://orcid.org/0000-0002-2843-6100)
- Huipeng Fang
- Hong Liang (ORCID: https://orcid.org/0000-0002-9148-8894)
- Junxin Wu (ORCID: https://orcid.org/0000-0003-1047-2338)
- Lei Wang (ORCID: https://orcid.org/0000-0001-6604-3175)
- Shiji Wu
Institutions
- Fujian Medical University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Jiangxi Provincial Cancer Hospital (CN)
- Fujian Provincial Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-03
- DOI
- https://doi.org/10.3389/fimmu.2024.1466226
- Citations
- 7
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.98