The dual role of glucocorticoid regeneration in inflammation at parturition
There is a feed-forward cortisol regeneration in the fetal membranes in infection, and cortisol regenerated restrains pro-inflammatory cytokine expression, while reserves pro-labor effect on prostaglandin synthesis. This dual role of cortisol regeneration can prevent excessive pro-inflammatory cytokine production, while ensure in-time delivery for the safety of the fetus.
Authors
- Wen‐Jia Lei
- Meng‐Die Li (ORCID: https://orcid.org/0000-0001-5817-4482)
- Li-Jun Ling
- Wangsheng Wang (ORCID: https://orcid.org/0000-0003-1429-9237)
- Kang Sun (ORCID: https://orcid.org/0000-0003-2727-141X)
- Fan Zhang (ORCID: https://orcid.org/0000-0002-2491-3600)
- Hao Ying (ORCID: https://orcid.org/0000-0003-0824-9348)
- Jiang‐Wen Lu (ORCID: https://orcid.org/0000-0002-1172-5723)
- Qiong Zhou (ORCID: https://orcid.org/0009-0006-3077-2425)
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shanghai First Maternity and Infant Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-03
- DOI
- https://doi.org/10.3389/fimmu.2024.1459489
- Citations
- 2
- Primary Topic
- Preterm Birth and Chorioamnionitis
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Program of Shanghai Academic Research Leader