Evaluating TRAIL and IP-10 alterations in vaccinated pregnant women after COVID-19 diagnosis and their correlation with neutralizing antibodies
Our study suggests that lower maternal TRAIL and higher IP-10 levels compared to neonatal cord blood coupled with a rise in both markers following COVID-19 diagnosis that could be reduced by antivirals indicates a correlation to infection severity. Higher vaccine doses enhance Nab inhibition, irrespective of antiviral medication use and independent of TRAIL or IP-10 levels, highlighting the significance and safety of adequate vaccination and antiviral use post-diagnosis in pregnant women.
Authors
- Chao‐Min Cheng (ORCID: https://orcid.org/0000-0002-8644-1960)
- Wei‐Chun Chen (ORCID: https://orcid.org/0000-0002-6515-0996)
- Ching‐Fen Shen
- Shu-Yu Hu
- Hui-Yu Chuang
- Chin-Ru Ker (ORCID: https://orcid.org/0000-0002-8656-1858)
- Der-Ji Sun
- Ching‐Ju Shen (ORCID: https://orcid.org/0000-0002-9975-4210)
Institutions
- Kaohsiung Medical University (TW)
- Chang Gung University (TW)
- National Tsing Hua University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Linkou Chang Gung Memorial Hospital (TW)
- Pojen General Hospital (TW)
- National Cheng Kung University Hospital (TW)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-03
- DOI
- https://doi.org/10.3389/fimmu.2024.1415561
- Citations
- 1
- Primary Topic
- COVID-19 Impact on Reproduction
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- Chang Gung Medical Foundation
- Kaohsiung Medical University
- Kaohsiung Medical University Chung-Ho Memorial Hospital
- National Science and Technology Council