Concise Synthesis of Azaphenanthrene Alkaloid Eupolauramine Via Au(I)‐Catalyzed Cycloisomerization and Intramolecular Ullmann‐Type Coupling Reaction

ABSTRACT A concise and efficient synthesis of the γ‐lactam‐fused azaphenanthrene alkaloid eupolauramine has been achieved. The key feature of the synthesis involves Au(I)‐catalyzed cycloisomerization of N ‐naphthyl aminobutynamide intermediate and subsequent intramolecular Ullmann‐type coupling reaction. This study clearly demonstrated the usefulness of coinage metal‐catalyzed cycloisomerization strategy in the construction of architecturally sophisticated pyridine‐fused heterocyclic scaffolds.