Reward system neurodynamics during menstrual pain modulated by COMT Val158Met polymorphisms
This study reveals that the <i>COMT</i> Val158Met polymorphism results in genotype-specific functional changes in the brain's RS during menstrual pain. In Met carriers, engagement of these regions is potentially linked to motivational reward-seeking and top-down modulation. This polymorphism likely influences the RS's responses, significantly contributing to individual differences in pain regulation.
Authors
- Jen‐Chuen Hsieh (ORCID: https://orcid.org/0000-0002-7568-000X)
- Ching‐Hsiung Liu (ORCID: https://orcid.org/0000-0002-1174-473X)
- Lin-Chien Lee
- Ming‐Wei Lin (ORCID: https://orcid.org/0000-0002-5471-7731)
- Ching‐Ju Yang (ORCID: https://orcid.org/0000-0001-5324-8112)
- Wei‐Chi Li (ORCID: https://orcid.org/0000-0002-4537-9291)
- Pei-Shan Hsu (ORCID: https://orcid.org/0000-0001-6840-3082)
- Li‐Fen Chen (ORCID: https://orcid.org/0000-0002-3819-853X)
- Hsiang-Tai Chao
Institutions
- National Yang Ming Chiao Tung University (TW)
- Luodong Poh-Ai Hospital (TW)
- Taipei Veterans General Hospital (TW)
- Taipei Tzu Chi Hospital (TW)
- Cheng Hsin General Hospital (TW)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2024-09-03
- DOI
- https://doi.org/10.3389/fnmol.2024.1457602
- Citations
- 1
- Primary Topic
- Musculoskeletal pain and rehabilitation
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- National Science Council
- National Yang-Ming University
- National Taiwan University Hospital
- Taipei Veterans General Hospital
- National Science and Technology Council