Drug-drug interaction between diltiazem and tacrolimus in relation to CYP3A5 genotype status in Chinese pediatric patients with nephrotic range proteinuria: a retrospective study
Diltiazem significantly increased tacrolimus C<sub>0</sub>/D, with CYP3A5*3 expressers showing higher elevations than non-expressers among pediatric NRP patients. These findings highlight the importance of personalized tacrolimus therapy based on CYP3A5*3 genotypes in pediatric patients taking diltiazem.
Authors
- Wenyan Huang (ORCID: https://orcid.org/0000-0002-2197-0781)
- Ping Wang (ORCID: https://orcid.org/0000-0002-8640-1483)
- Hongxia Liu (ORCID: https://orcid.org/0000-0003-4547-0666)
- Yijun Li (ORCID: https://orcid.org/0000-0002-4913-0143)
- Yan Wang (ORCID: https://orcid.org/0000-0002-6298-8806)
- Xuebin Wang (ORCID: https://orcid.org/0000-0003-4270-7330)
- Qiaoling Yang (ORCID: https://orcid.org/0000-0002-7462-2510)
- Huajun Sun (ORCID: https://orcid.org/0000-0003-3768-7048)
- Boyu Tan
Institutions
- Shanghai Jiao Tong University (CN)
- Chengdu Medical College (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Chengdu University (CN)
- Shanghai Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-03
- DOI
- https://doi.org/10.3389/fphar.2024.1463595
- Citations
- 4
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Natural Science Foundation of Shanghai
- Shanghai Jiao Tong University