Clozapine may consistently protect from suicidal behaviors while other antipsychotics may lack a specific protective effect: a comprehensive VigiBase study interpreted in the context of the prior literature
This pharmacovigilance study, with all its inherent limitations, provides independent proof, not overlapping with prior literature, that clozapine may have specific strong anti-suicidal effects that do not appear to be present in other antipsychotics. Further VigiBase studies are needed to compare the lethality of an intentional overdose of clozapine (14.3%) with other antipsychotics.
Authors
- Emílio J. Sanz (ORCID: https://orcid.org/0000-0001-6788-4435)
- Carlos De las Cuevas (ORCID: https://orcid.org/0000-0001-5742-905X)
- Hilario Blasco‐Fontecilla (ORCID: https://orcid.org/0000-0002-2864-6298)
- Victoria de León-Martínez (ORCID: https://orcid.org/0000-0002-5811-2086)
- Enrique Baca‐García (ORCID: https://orcid.org/0000-0002-6963-6555)
- Marina Šagud (ORCID: https://orcid.org/0000-0001-9620-2181)
- José de León (ORCID: https://orcid.org/0000-0002-7756-2314)
Institutions
- Universidad Complutense de Madrid (ES)
- University Hospital Centre Zagreb (HR)
- Universidad de La Laguna (ES)
- University of the Basque Country (ES)
- University of Zagreb (HR)
- Washington University in St. Louis (US)
- Catholic University of the Maule (CL)
- Hospital Universitario de Canarias (ES)
- Instituto de Salud Carlos III (ES)
- Eastern State Hospital (US)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Espoo Music Institute (FI)
- Centre Hospitalier Universitaire de Nîmes (FR)
- Hospital Santiago Apostol (ES)
- Universidad Internacional De La Rioja (ES)
- Hospital Universitario Fundación Jiménez Díaz (ES)
Publication Details
- Journal
- Expert Opinion on Drug Safety
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1080/14740338.2024.2399094
- Citations
- 17
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.55
Funders
- World Health Organization