Brain morphological analysis in mice with hyperactivation of the hedgehog signaling pathway
Hedgehog signaling is a highly conserved pathway that plays pivotal roles in morphogenesis, tumorigenesis, osteogenesis, and wound healing. Previous investigations in patients with Gorlin syndrome found low harm avoidance traits, and increased volumes in the cerebrum, cerebellum, and cerebral ventricles, suggesting the association between brain morphology and the constitutive hyperactivation of hedgehog signaling, while the changes of regional brain volumes in upregulated hedgehog signaling pathway remains unclear so far. Herein, we investigated comprehensive brain regional volumes using quantitative structural brain MRI, and identified increased volumes of amygdala, striatum, and pallidum on the global segmentation, and increased volumes of the lateral and medial parts of the central nucleus of the amygdala on the detail segmentation in Ptch heterozygous deletion mice. Our data may enhance comprehension of the association between brain morphogenic changes and hyperactivity in hedgehog signaling.
Authors
- Shingo Matsuda (ORCID: https://orcid.org/0000-0002-0763-0799)
- Hiromichi Hamada (ORCID: https://orcid.org/0000-0002-8990-5265)
- Katsunori Fujii (ORCID: https://orcid.org/0000-0002-8937-0547)
- Ichio Aoki (ORCID: https://orcid.org/0000-0002-4429-5053)
- Tomozumi Takatani
- Nobuhiro Nitta
- Eiji Shimizu (ORCID: https://orcid.org/0000-0002-6741-9338)
- Emi Takahashi (ORCID: https://orcid.org/0000-0001-9820-3356)
- Alpen Ortuğ (ORCID: https://orcid.org/0000-0002-6813-8351)
- Hideki Uchikawa
- Daisuke Sawada (ORCID: https://orcid.org/0000-0002-5789-2551)
- Tadashi Shiohama (ORCID: https://orcid.org/0000-0003-0076-5882)
Institutions
- Harvard University (US)
- Chiba University (JP)
- Massachusetts General Hospital (US)
- National Center of Neurology and Psychiatry (JP)
- National Institutes for Quantum Science and Technology (JP)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- International University of Health and Welfare (JP)
- Showa Pharmaceutical University (JP)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2024-09-03
- DOI
- https://doi.org/10.3389/fnins.2024.1449673
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science
- RIKEN
- Co-creation place formation support program