Differential immunological profiles in seronegative versus seropositive rheumatoid arthritis: Th17/Treg dysregulation and IL-4
Th17/Treg imbalance is one of the vital immunological disparities between SnRA and SpRA. Interestingly, PsA and SnRA display similar peripheral blood immunological profiles, providing immunological evidence for these two diseases' clinical and pathological similarities. Furthermore, IL-4 emerges as the central immunological disparity marker between SnRA and SpRA, suggesting its potential role as a triggering mechanism for differential antibody production.
Authors
- Baochen Li (ORCID: https://orcid.org/0000-0001-5593-9697)
- Chong Gao (ORCID: https://orcid.org/0000-0001-7639-0808)
- R. Su
- Xiaofeng Li (ORCID: https://orcid.org/0000-0002-3946-5791)
- Rui Su (ORCID: https://orcid.org/0000-0002-4807-6229)
- Caihong Wang (ORCID: https://orcid.org/0000-0003-0817-7946)
- Qiaoling Guo
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Shanxi Medical University (CN)
- Changzhi Medical College (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-03
- DOI
- https://doi.org/10.3389/fimmu.2024.1447213
- Citations
- 11
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 5.17
Funders
- National Natural Science Foundation of China