PCL-gelatin honey scaffolds promote Staphylococcus aureus agrA expression in biofilms with Pseudomonas aeruginosa
Soluble Manuka honey inhibited the planktonic and biofilm growth of both <i>S. aureus</i> (UWH3) and <i>P. aeruginosa</i> (PA14) co-cultures. Manuka honey embedded PCL-gelatin scaffolds did not exhibit bacteriostatic or bactericidal effects on cocultures of UHW3 and PA14; however, they promoted the expression of <i>AgrA</i>, a gene associated with dispersal of <i>S. aureus</i> biofilms.
Authors
- Laurie P. Shornick (ORCID: https://orcid.org/0000-0001-6652-1878)
- Rowena Jenkins (ORCID: https://orcid.org/0000-0001-6664-6099)
- Genevieve Hilliard
- Llinos G. Harris (ORCID: https://orcid.org/0000-0002-0295-3038)
- Thomas S. Wilkinson (ORCID: https://orcid.org/0000-0003-0397-6079)
Institutions
- Swansea University (GB)
- Saint Louis University (US)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-09-03
- DOI
- https://doi.org/10.3389/fmicb.2024.1440658
- Citations
- 5
- Primary Topic
- Bee Products Chemical Analysis
- Type
- article
- Field-Weighted Citation Impact
- 2.70