The influence of Helicobacter pylori infection on acute coronary syndrome and lipid metabolism in the Chinese ethnicity

Our study has demonstrated for the first time that <i>H. pylori</i> does not significantly impact lipid metabolism but increases the risk of ACS fourfold in the Chinese population (OR = 4.04, 95% CI: 1.76-9.25). Furthermore, the virulence factors of <i>H. pylori</i> (<i>CagA</i> and <i>VacA</i>) may not be involved in the mechanisms by which they promote the development of ACS. This finding provides additional evidence for the association between <i>H. pylori</i> and ACS among different ethnic groups and refutes the biological mechanism by which <i>H. pylori</i> affects ACS through lipid metabolism regulation. Regular screening for <i>H. pylori</i> and eradication treatment in elderly individuals and those at high risk for ACS may be effective measures for reducing the incidence of ACS. Future research should include multicenter randomized controlled trials and explore host genetics and the effects of <i>H. pylori</i> on the gut microbiota as potential biological pathways linking <i>H. pylori</i> and ACS.