Polarized benzene rings can promote the interaction between CaM and the CaMBD region of nNOS
In summary, this study explored the ability and mode of action of key residues in nNOS-CaMBD on the binding of interfering peptides to CaM, thereby providing new structural perspectives for the activation of nNOS by CaM and recommendations for drug design targeting the specific inhibition of nNOS.
Authors
- Nan Wang (ORCID: https://orcid.org/0000-0001-7129-6089)
- Wei Wan (ORCID: https://orcid.org/0000-0001-9462-5615)
Institutions
- Xuzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2024-09-03
- DOI
- https://doi.org/10.3389/fnmol.2024.1461272
- Citations
- 1
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.33