Targeting SRSF10 might inhibit M2 macrophage polarization and potentiate anti‐PD‐1 therapy in hepatocellular carcinoma
The SRSF10/MYB/glycolysis/lactate axis is critical for triggering immune evasion and anti-PD-1 resistance. Inhibiting SRSF10 by 1C8 may overcome anti-PD-1 tolerance in HCC.
Authors
- Jing-Lei Wan (ORCID: https://orcid.org/0000-0001-6466-6061)
- Jun-Xian Du
- Shiping Chen (ORCID: https://orcid.org/0000-0002-4603-0024)
- Jian Zhou (ORCID: https://orcid.org/0000-0002-8654-6439)
- Suiyi Wu (ORCID: https://orcid.org/0000-0002-1212-994X)
- Gui‐Qi Zhu (ORCID: https://orcid.org/0000-0001-5089-6923)
- Zhi Dai (ORCID: https://orcid.org/0000-0002-4032-9201)
- Feng Zhang (ORCID: https://orcid.org/0000-0003-4556-8276)
- Jia Fan
- Yufan Cai
- Jialiang Cai
- Lina Song (ORCID: https://orcid.org/0000-0001-5182-7831)
- Yi Yang (ORCID: https://orcid.org/0009-0009-7760-333X)
- Peiling Zhang
- Biao Wang (ORCID: https://orcid.org/0000-0002-2536-819X)
Institutions
- Academy of Medical Sciences (GB)
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Cancer Institute (WIA) (IN)
- Zhongshan Hospital (CN)
- Cancer Research Center (US)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shanghai Institute of Hematology (CN)
- State Key Laboratory of Genetic Engineering
Publication Details
- Journal
- Cancer Communications
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1002/cac2.12607
- Citations
- 120
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 28.06
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China