Insulin-like growth factor-2 mRNA-binding protein 2 facilitates post-ischemic angiogenesis by increasing the stability of fibroblast growth factor 2 mRNA and its protein expression
IGF2BP2 contributes to blood flow restoration post-ischemia <i>in vivo</i> and promotes angiogenesis in HUVECs by enhancing <i>FGF2</i> mRNA stability and FGF2 protein expression and secretion. These findings underscore IGF2BP2's therapeutic potential in ischemic conditions, such as PAD.
Authors
- Xinyu Xu (ORCID: https://orcid.org/0000-0002-8584-9382)
- Panke Chen
- Yiqing Hu (ORCID: https://orcid.org/0000-0002-1813-9778)
- Hao Lu (ORCID: https://orcid.org/0009-0002-2168-7270)
- Ying Wang (ORCID: https://orcid.org/0000-0003-4524-1812)
- Weidong Xiong (ORCID: https://orcid.org/0009-0000-4244-3713)
- Yongchao Zhao (ORCID: https://orcid.org/0000-0002-2145-7187)
- Wenbi Yang
- Wangguo Xu
- Yajie Hou
- Shuai Ma (ORCID: https://orcid.org/0000-0003-3452-1739)
Institutions
- Zunyi Medical University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e37364
- Citations
- 1
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Natural Science Foundation of China
- Fudan University
- Shanghai Medical College, Fudan University