Cognitive and Histopathological Alterations in Rat Models of Early- and Late-Phase Memory Dysfunction: Effects of Sigma-1 Receptor Activation
Future studies are thus necessary to address the effects of long-lasting (±)-PPCC treatment, with or without clonidine, on cognitive abilities and Alzheimer's disease-like histopathology. Considering the already established involvement of sigma-1 receptors in endogenous cell plasticity mechanisms, their activation by selective agonist compounds holds promises as possibly positive contributor to disease-modifying events in neurodegenerative diseases.
Authors
- Rosario Gulino (ORCID: https://orcid.org/0000-0002-8067-697X)
- Anna Kostenko
- Antonella Caccamo (ORCID: https://orcid.org/0000-0003-2615-1133)
- Orazio Prezzavento (ORCID: https://orcid.org/0000-0002-3521-264X)
- Giampiero Leanza (ORCID: https://orcid.org/0000-0002-8609-2561)
- Gioacchino de Leo (ORCID: https://orcid.org/0000-0001-8636-2851)
- David D’Arco
Institutions
- University of Messina (IT)
- Scuola Internazionale Superiore di Studi Avanzati (IT)
- University of Trieste (IT)
- University of Catania (IT)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-09-03
- DOI
- https://doi.org/10.3233/jad-240618
- Primary Topic
- Pharmacological Receptor Mechanisms and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00