Electrochemotherapy and Calcium Electroporation on Hepatocellular Carcinoma Cells: An In-Vitro Investigation
Electrochemotherapy with bleomycin or cisplatin, or calcium electroporation were more effective in reducing the HepG2 cell viability in vitro using the ESOPE protocol compared to the non-electroporated drug treatments alone. When comparing electrochemotherapy, HepG2 cells are more sensitive to bleomycin than cisplatin, in similar concentrations. Calcium electroporation has the same effectiveness as electrochemotherapy with bleomycin, but calcium potentially has a better safety profile and several treatment advantages.
Authors
- Andreas Ritter (ORCID: https://orcid.org/0000-0001-7462-8632)
- Teresa Lemainque (ORCID: https://orcid.org/0000-0003-3167-7121)
- Ralph Maessen
- Marco Baragona (ORCID: https://orcid.org/0000-0002-5347-4731)
- Kim. H. K. Lindelauf (ORCID: https://orcid.org/0000-0001-7758-0451)
Institutions
- Philips (United Kingdom) (GB)
- Universitätsklinikum Aachen (DE)
- Philips (Netherlands) (NL)
- RWTH Aachen University (DE)
Publication Details
- Journal
- CardioVascular and Interventional Radiology
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1007/s00270-024-03847-1
- Primary Topic
- Microbial Inactivation Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Horizon 2020 Framework Programme
- H2020 Marie Skłodowska-Curie Actions