Sonic Hedgehog reduces inflammatory response, decreases blood-spinal cord barrier permeability, and improves locomotor function recovery in an acute spinal cord injury rat model
Shh application at 7 days post-injury showed immunomodulatory effects, possibly via enhanced blood-spinal cord barrier integrity, reduced immune cell migration, and increased anti-inflammatory immune cell differentiation. These mechanisms collectively contribute to enhanced locomotor recovery.
Authors
- Mohamed Tail
- Andreas Unterberg (ORCID: https://orcid.org/0000-0003-3742-3288)
- Anna-Kathrin Harms
- Alexander Younsi (ORCID: https://orcid.org/0000-0002-8218-9243)
- Thomas Skutella (ORCID: https://orcid.org/0000-0003-4813-1213)
- Klaus Zweckberger
- Hao Zhang (ORCID: https://orcid.org/0000-0002-0206-9066)
- Karl Kiening
- Guoli Zheng (ORCID: https://orcid.org/0000-0002-7875-6006)
- Maryam Hatami
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
Publication Details
- Journal
- Journal of Inflammation
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1186/s12950-024-00404-y
- Citations
- 6
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Universitätsklinikum Heidelberg