Neurological Symptoms and Cause of Death Among Young Children in Low- and Middle-Income Countries

In this cross-sectional study of children aged younger than 5 years, neurological symptoms were frequent before death. However, clinical phenotypes were insufficient to differentiate the most common underlying neurological diagnoses. The low rate of lumbar punctures performed was especially worrying, suggesting a challenge in quality of care of children presenting with neurological symptoms. Improved diagnostic management of neurological emergencies is necessary to ultimately reduce mortality in this vulnerable population.

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Journal
JAMA Network Open
Published
2024-09-03
DOI
https://doi.org/10.1001/jamanetworkopen.2024.31512
Citations
4
Primary Topic
Autopsy Techniques and Outcomes
Type
article
Field-Weighted Citation Impact
1.62
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article

Neurological Symptoms and Cause of Death Among Young Children in Low- and Middle-Income Countries

Yasmin Adam, Roosecelis B. Martines, George Aol, Soter Ameh et al.
4 citations
JAMA Network Open
Autopsy Techniques and Outcomes
1.62
article

Neurological Symptoms and Cause of Death Among Young Children in Low- and Middle-Income Countries

Yasmin Adam, Roosecelis B. Martines, George Aol, Soter Ameh, Karen D. Fairchild, Dickson Gethi, Solveig A. Cunningham, Jana M. Ritter, Dickens Kowuor, Mischka Garel, María Maixenchs, Tadesse Gure, Francis Smart, Dianna M. Blau, Ronita Luke, Shahana Parveen, Nana Kourouma, Alim Swarray‐Deen, Gillian Sorour, James Sylvester Squire, Fikremelekot Temesgen, Solomon Samura, Dilruba Ahmed, Khátia Munguambe, Nelesh Premapragasan Govender, Peter Nyamthimba Onyango, Maureen H. Diaz, Melisachew Mulatu Yeshi, James Bunn, Clara Menéndez, Kyu Han Lee, Janet Agaya, Taís Meziara Wilson, Jeffrey P. Koplan, Mustafizur Rahman, Jennifer Johnson, Tahmina Shirin, Peter J. Swart, Joseph Kamanda Sesay, John Blevins, Richard Oliech, Karen L. Kotloff, Jonas M. Winchell, Mahlet Abayneh Gizaw, Inácio Mandomando, Amy Wise, Lola Madrid, Julius Ojulong, Kristin LaHatte, Shailesh Nair, Brigitte Gaume, Samuel Pratt, Victor Akelo, Margaret Mannah, Rima Koka, Addisu Alemu, Diakaridia Sidibé, Sana Mahtab, Hennie Lombaard, Jeannette Wadula, Zachary J. Madewell, Erick Kaluma, Nellie Myburgh, Martin Hale, Sartie Kenneh, Thomas Misore, ASM Nawshad Uddin Ahmed, Portia Mutevedzi, Karen L. Petersen, Samba O. Sow, Manu Bhandari, Shams El Arifeen, Hailemariam Legesse, Sara Ajanovic, Milagritos D. Tapia, Ikechukwu U. Ogbuanu, Emily S. Gurley, Meerjady Sabrina Flora, Navit T. Salzberg, Joyce Were, Lucy Liu, Kiranpreet Chawla, Cynthia G. Whitney, Diakaridia Kone, Doh Sanogo, Sharon M. Tennant, Shabir Ahmed Madhi, Nega Assefa, Babatunde Duduyemi, Jeanie du Toit, Rosauro Varo, Elísio Xerinda, Beth A. Tippett Barr, Richard Chawana, Tom Sesay, Francis Moses, Quique Bassat, Solomon Ali, Jeffrey N. Bone, Okokon Ita, Alexander M. Ibrahim, Amara Jambai, Sithembiso Velaphi, Khalequ Zaman, Kitiezo Aggrey Igunza, Ziyaad Dangor, Zara Manhique, Princewill Nwajiobi, Cornell Chukwuegbo, Andrew Moseray, Milton Kincardett, Harun Owuor, Fatmata Bintu Tarawally, Martin Seppeh, Osman Kaykay, Binyam Halu, Jakob Witherbee, Shamta Warang, Sarah Raymer, Farida Ariuman, Bernard Oluoch, Christine Ochola, Afruna Rahman, Mohammad Mosiur Rahman, Ronald Mash, Saria Tasnim, Mahbubur Rahman, Gunturu Revathi, Mohammed Kamal, Ashka Mehta, Kazi Munisul Islam, Stian MS Orlien, Adama Mamby Keita, Tacilta Nhampossa, Kurt Vyas, Mohammad Zahid Hossain, Sanwarul Bari, Mohammednur Abdulahi, Uma U. Onwuchekwa, Cheik Bougadari Traor, Mahbubul Hoque, Courtney Bursuc Liu, Joseph Oundo, Oluseyi Balogun, Sulaiman Sannoh, Seydou Sissoko, Ariel Nhacolo, Joseph Bangura, Cheick Bougadari Traoré, Awa Traoré, Ferdousi Begum, Florence Murila, Phillip Nwajiobi-Princewill, Christopher Muga, Jessica L. Waller, Peter Otieno, Kounandji Diarra, Ferdousi Islam, Sanjay G. Lala, Tiéman Diarra, Carrie Jo Cain, Jane Juma, Mugah A. Christopher, Carol L. Greene, Fatima Solomon
article en
4 citations

Abstract

In this cross-sectional study of children aged younger than 5 years, neurological symptoms were frequent before death. However, clinical phenotypes were insufficient to differentiate the most common underlying neurological diagnoses. The low rate of lumbar punctures performed was especially worrying, suggesting a challenge in quality of care of children presenting with neurological symptoms. Improved diagnostic management of neurological emergencies is necessary to ultimately reduce mortality in this vulnerable population.

JAMA Network OpenVol. 7(9)
South African Medical Research Council (ZA), Institució Catalana de Recerca i Estudis Avançats (ES), University of Maryland, Baltimore (US), Centers for Disease Control and Prevention (US), Hospital Sant Joan de Déu Barcelona (ES), University of Ghana (GH), Johns Hopkins University (US), Emory University (US), Haramaya University (ET), University of the Witwatersrand (ZA), International Centre for Diarrhoeal Disease Research (BD), Aga Khan University Hospital Nairobi (KE), Kenya Medical Research Institute (KE), Centre Pour le Développement des Vaccins-Mali (ML), London School of Hygiene & Tropical Medicine (GB), National Hospital Abuja (NG), Aga Khan University Nairobi (KE), Manhiça Health Research Centre (MZ), Instituto Nacional de Saúde (MZ), Centers for Disease Control and Prevention (KE), Barcelona Institute for Global Health (ES), Sierra Leone Urban Research Centre (SL), Addis Ababa University (ET), Universitat de Barcelona (ES), Mekelle University (ET), Great Lakes University of Kisumu (KE)
Openalex Percentile: Top 16%
Autopsy Techniques and Outcomes
1.62
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