Segregation GWAS to linearize a non-additive locus with incomplete penetrance: an example of horn status in sheep
Our results show clear differences in penetrance values between males and female Merino sheep for horn status. Segregation analysis for a trait with mutually exclusive phenotypes, non-additive inheritance, and/or incomplete penetrance can lead to considerably more power in a GWAS because the linearized genotype probabilities are additive and can accommodate incomplete penetrance. This method can be extended to any monogenic controlled categorical trait of which the phenotypes are mutually exclusive.
Authors
- J. H. J. van der Werf (ORCID: https://orcid.org/0000-0003-2512-1696)
- Naomi Duijvesteijn (ORCID: https://orcid.org/0000-0001-9984-6177)
- Brian Kinghorn
Institutions
- Hendrix Genetics (Netherlands) (NL)
- Poultry CRC (AU)
- University of New England (AU)
Publication Details
- Journal
- Genetics Selection Evolution
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1186/s12711-024-00928-0
- Citations
- 5
- Primary Topic
- Genetic and phenotypic traits in livestock
- Type
- article
- Field-Weighted Citation Impact
- 2.75
Funders
- Australian Wool Innovation